Abstract

Background: The polyomaviruses that infect humans, BK virus (BKV), JC virus (JCV), and simian virus 40 (SV40), typically establish subclinical persistent infections. However, reactivation of these viruses in immunocompromised hosts is associated with renal nephropathy and hemorrhagic cystitis (HC) caused by BKV and with progressive multifocal leukoencephalopathy (PML) caused by JCV. Additionally, SV40 is associated with several types of human cancers including primary brain and bone cancers, mesotheliomas, and non- Hodgkin#x2019;s lymphoma. Aims: To study of SV40, BKV and JCV in Esophageal and Colorectal cancer Patients in Khartoum State, Sudan. Objective: This study was designed to detect BKV, JCV, and SV40 among colorectal cancer and esophageal cancer patients in Khartoum State, Sudan during the period October 2018 to July 2019.