Injectable fillers are used in aesthetic medicine to reduce visible signs of facial aging. It involves loss of volume in the skin, muscle and superficial and deep fat compartments, superficial wrinkles and deep folds (1-2). There are different products that vary on filling capacity, longevity, potentiality for causing allergic reaction, safety, indication. Physicians select the most suitable agent for each patient by considering the advantage and disadvantage. In fact, hyaluronic acid (HA) has the property to increase the skin's water-binding capacity (3-5). Calcium hydroxylapatite (6) and poly-L-lactic acid (7) have been proved to stimulate autologous collagen (8-9).