Pre-Life exposure relates to development during the time preceding the first appearance of life, a time course from “conception to confinement”. From single cell zygote to finally formed fetus at confinement, a remarkable change occurs due to maternal fuels and hormonal influence on the fetal development. The crucial period in the fetal development is the first trimester. Early exposure to aberrant maternal metabolism in the embryonic developmental stage would result in congenital malformation and fetal wastage. Maintaining maternal glucose at the recommended level of fasting80 – 90 mg (4.4 – 5.0 mmol/dl) and 2hr postprandial plasma glucose 110 – 120 mg/dl (6.1 -6.7 mm0l/dl) during preconceptional period and throughout pregnancy is the assurance for the healthy offspring with ideal birth weight of 2.5 to 3.5 kg and breastfeeding is “a step towards strategy forprevention of diabetes”.