Covid-19 Infection: Prerequisites for New Areas of Research

Iskandar R. Mavlanov; #x410;bdurashid Kh. #x410;shirmetov; Ziyodulla I.  Mavlanov; Gavkhar J. Jarylkasimova

Authors

Iskandar R. Mavlanov
#x410;bdurashid Kh. #x410;shirmetov
Ziyodulla I. Mavlanov
Gavkhar J. Jarylkasimova

Keywords:

coronavirus, COVID-19, drugs, toxic and side effects, gene polymorphism, pharmacogenetics, therapy personification

Abstract

The pandemic of COVID-19 infection caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2) has posed a significant threat to global health. Now, we have witnessed an unsurpassed increase in the number of clinical trials worldwide. In clinical trials old and new drugs are tested as potential treatments either for their direct anti-viral activity, or for their ability to provide management of respiratory and cardiovascular symptoms and complications, characteristic of COVID-19. Despite the worsening trends of COVID-19, no drugs are validated to have significant efficacy in clinical treatment of COVID-19 patients in large-scale studies. Such a strategy is likely to give rise to a range of safety and efficacy challenges that could be addressed through preliminary pharmaco-genetic research on identification of risk groups for personification of therapy approach. Addressing the personification of drug treatment COVID-19 becomes an urgent need to interpret the conflicting results of clinical trials and establish the apparent efficacy of any particular drug.

Downloads

How to Cite

Covid-19 Infection: Prerequisites for New Areas of Research. (2021). Global Journal of Medical Research, 20(K14), 35-38. https://medicalresearchjournal.org/index.php/GJMR/article/view/2349

Download Citation

References

B Mccloskey, D Heymann (2020) SARS to novel coronavirus: old lessons and new lessons. 22, e22.

M Majumder, K Mandl (2020) Early in the epidemic: impact of preprints on global discourse about COVID-19 transmissibility.

W Liu, J Morse, T Lalonde (2020) Learning from the past: possible urgent prevention and treatment options for severe acute respiratory infections caused by 2019-nCoV. 21(5), 730-738.

Markus Hoffmann, Hannah Kleine-Weber, Nadine Krüger, Marcel Müller, Christian Drosten, Stefan Pöhlmann (2020) The novel coronavirus 2019 (2019-nCoV) uses the SARS-coronavirus receptor ACE2 and the cellular protease TMPRSS2 for entry into target cells. 2022-2023.

Taisheng Li, Hongzhou Lu, Wenhong Zhang (2020) Clinical observation and management of COVID-19 patients. 9(1), 687-690.

Zsuzsanna Varga, Andreas Flammer, Peter Steiger, Martina Haberecker, Rea Andermatt, Annelies Zinkernagel, Mandeep Mehra, Reto Schuepbach, Frank Ruschitzka, Holger Moch (2020) Endothelial cell infection and endotheliitis in COVID-19. 395(10234), 1417-1418.

Maria Dalamaga, Irene Karampela, Christos Mantzoros (2020) Commentary: Could iron chelators prove to be useful as an adjunct to COVID-19 Treatment Regimens?. 108, 154260.

Felice Rivellese, Edoardo Prediletto (2020) ACE2 at the centre of COVID-19 from paucisymptomatic infections to severe pneumonia. 19(6), 102536.

C Qin, L Zhou, Z Hu (2020) Dysregulation of immune response in patients with COVID-19 in Wuhan.

Geng Li, Yaohua Fan, Yanni Lai, Tiantian Han, Zonghui Li, Peiwen Zhou, Pan Pan, Wenbiao Wang, Dingwen Hu, Xiaohong Liu, Qiwei Zhang, Jianguo Wu (2020) Coronavirus infections and immune responses. 92(4), 424-432.

E Prompetchara, C Ketloy, T Palaga (2020) Immune responses in COVID-19 and potential vaccines: Lessons learned from SARS and MERS epidemic. 38, 1-9.

Allison Totura, Ralph Baric (2012) SARS coronavirus pathogenesis: host innate immune responses and viral antagonism of interferon. 2(3), 264-275.

Savannah Pedersen, Ya-Chi Ho (2020) SARS-CoV-2: a storm is raging. 130(5), 2202-2205.

H Harapan, N Itoh, A Yufika (2020) Coronavirus disease 2019 (COVID-19): A literature review. 13, 667-673.

W Liu, H Li (2020) COVID-19: Attacks the 1-Beta chain of hemoglobin and captures the Porphyrin to inhibit human Heme metabolism.

H Drakesmith, A Prentice (2008) Viral infection and iron metabolism. 6, 541-552.

Marianne Wessling-Resnick (2010) Iron Homeostasis and the Inflammatory Response. 30(1), 105-122.

Md Ali, Richard Kim, Alexandra Brown, Chantal Donovan, Kanth Vanka, Jemma Mayall, Gang Liu, Amber Pillar, Bernadette Jones‐freeman, Dikaia Xenaki, Theo Borghuis, Rafia Karim, James Pinkerton, Ritambhara Aryal, Moones Heidari, Kristy Martin, Janette Burgess, Brian Oliver, Debbie Trinder, Daniel Johnstone, Elizabeth Milward, Philip Hansbro, Jay Horvat (2020) Critical role for iron accumulation in the pathogenesis of fibrotic lung disease. 251(1), 49-62.

Ennio Favalli, Francesca Ingegnoli, Orazio De Lucia, Gilberto Cincinelli, Rolando Cimaz, Roberto Caporali (2020) COVID-19 infection and rheumatoid arthritis: Faraway, so close!. 19(5), 102523.