Exercise is inevitable to keep health in good status. There are few scientific studies to show the differences between different types of exercises in health and disease. In our study we compared the treadmill exercise and bicycle ergometer exercise and their effect on maximum heart rate attained, systolic blood pressure and diastolic blood pressure in twenty one healthy volunteer aged between eighteen to twenty years. We recorded these subjects’s blood pressure before exercise and after exercise; heart rate before exercise, during exercise and after exercise. Also we enlisted the advantages and disadvantages of treadmill exercise and bicycle ergometer exercise, so that these two types of exercise can be appropriately used for health promotion, diagnosis of diseases and for rehabilitation of the individuals.