Abstract

The COVID-19 is a zoonotic disease and is caused by the SARS-CoV-2 virus It is the type of coronavirus The structural proteins of the virus include the spike S protein membrane M protein envelop protein E and nucleocapsid N protein The replication of the virus utilizes all structural proteins The infection of the host occurs due to the binding of the spike protein to the angiotensin-converting enzyme II ACE II It is a positive-sense single-stranded RNA virus belong to the family Coronavridae The recent outbreak of this disease has caused a lethal pandemic The previous knowledge of SARS-CoV has helped to develop a vaccine against SARS-CoV-2 also The humoral and cell-mediated immune response is protective against this infection The antibody response generated against the S protein which is the most exposed protein of SARS-CoV has been shown to protect from infection in mouse models Multiple studies have shown that the antibodies generated against the N protein of SARS-CoV are highly immunogenic and abundantly expressed protein during infections