Objective: To study the association of placental adaptation of perinatal outcomes with hemodynamic values measured with USCOM. Methods: Case-control study nested in a cohort. We measured GC, IC, RVP and IRVP with non-invasive hemodynamics, at the end of pregnancy the perinatal result was recorded. Statistical analysis was performed with ROC curve for cutpoints, contingency tables, extreme reaction and linear regression. Results: N: 93 patients, the cut-off points were GC 5.5lt., IC3 lt., RVP 1200d in and IRVP 2500din. The IC<2.5lt. OR = 2.4 to develop adverse perinatal outcome (p<0.049), 100% preeclampsia had IC>3lt. In linear regression to assess RVP and GC, with presence of preeclampsia r2=0.857 (p<0.008); gestational diabetes r2 = 0.865, (p <0.05); Adverse perinatal result r2 = 0.803, (p<0.05); and perinatal death r2=0.969, (p<0.011). IC <3lt and IRVP>2500din.