Objective: In this study our main goal is to evaluate the incidence of lipoprotein disorder in patients with psoriasis attending tertiary care hospital in Bangladesh. Method: This case control study was carried out in the Department of Dermatology & Venereology, Chittagong Medical College Hospital (CMCH), Chittagong from June 15, 2013 to May 14, 2014. In this study; 60 patients with Psoriasis (group-A) and 60 patient with skin disease other than Psoriasis (group-B) were included according to availability within the study period. Results: During the study, it was found that; most of the patients were male among the psoriasis patients. Mean ±SD of weight was found 61.87±7.84 kg and height was found 1.62±0.05m among the psoriatic patients. There was a significant differences in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) between group A (Psoriasis) and group B (Skin diseases other then Psoriasis).