As a result of the study conducted, it was witnessed that the G allele and the heterozygous A / G genotype of the IL17F gene (rs763780) among patients with RA are significantly higher than in the control group. In particular, the most significant discrepancies were registered in patients with articular-visceral form of the disease whom the G allele exceeded the proportion of carriage in the control statistically significantly 2.58 times (χ2 = 4.512; P = 0.037; OR = 2.58; 95% CI: 1.076 -6.188). On the part of the heterozygous genotype A / G there was a clear tendency to increase its frequency by more than twice (χ2 = 2.011; P = 0.165; OR = 2.068; 95% CI: 0758-5.645) which in turn indicates the possible participation of the studied polymorphism in the pathogenesis of RA.

How to Cite
SH. KARIMOV, A. A. ESHMURZAEVA, KH. M. MARUFKHANOV, M. V. SIBIRKINA, M.. Association of Rs763780 Polymorphism of Gene IL17F with the Risk of Developing Rheumatoid Arthritis in Uzbekistan. Global Journal of Medical Research, [S.l.], sep. 2021. ISSN 2249-4618. Available at: <https://medicalresearchjournal.org/index.php/GJMR/article/view/2526>. Date accessed: 06 july 2022.

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