Background: Denture stomatitis is one of the common fungal infections that manifests over the edentulous ridges bearing dentures in patients using dentures. Commercially various synthetic substitutes are used for treatment of denture stomatitis. Various in-vitro studies showed that Punica granatum (Pomegranate) fruit is rich in nutraceutical & possess certain therapeutic properties such as antifungal activity Material & Method: Total of 30 patients suffering from denture stomatitis type I and type II were selected in the study. They were divided randomly into in two groups of 15 each. Group A - Patients treated with commercially available topical Clotrimazole. Group B - Patients treated with topical Punica granatum peel extract.