Back ground : Oral submucous fibrosis (OSF) is characterized by excessive production of collagen leading to inelasticity of the oral mucosa and atrophic changes of the epithelium. Aim : Aim of the study is to clinically evaluate the efficacy of oral Pentoxifylline 400 mg tablets in comparison to intralesional injections of Dexamethasone (4mg/ml) and Hyaluronidase 1500 IU and 0.5 ml of Lignocaine 2% in the management of OSF patients. Methodology : The study population consisted of 40 male patients with OSF. Patients were divided into two groups. 20 patients are in pentoxifylline group and 20 patients in Dexamethasone group. Pentoxifylline Group received oral Pentoxifylline 400 mg tablets twice daily for first 4 weeks and thrice daily for next 8 weeks. Dexamethasone Group received biweekly intralesional injections of Dexamethasone (4mg/ml), Hyaluronidase 1500 IU and 0.5 ml of Lignocaine 2% for a period of 12 weeks. Parameters taken in the study were burning sensation, mouth opening, tongue protrusion and cheek flexibility.