Influence of Anti Diabetic Therapy on Plasma Lipid Profile and Its Relation to Erythrocyte Membrane Lipid Levels in Type 2 Diabetic Subjects

Dr. Basavaraj.S.Aski; R.T.Kashinath; G. Rudrappa

Authors

Dr. Basavaraj.S.Aski
R.T.Kashinath
G. Rudrappa

Keywords:

RBC membrane lipids, anti diabetic drugs, plasma Lipids

Abstract

The diabetes induced dyslipidemia may lead to an alteration in RBC membrane cholesterol/phospholipids ratio in diabetic subjects resulting in an alteration in RBC membrane properties. It has been observed in our laboratory that diabetes induced dyslipidemia causes a change in RBC membrane lipid composition in type 2 diabetic subjects. The effect of various oral anti diabetic drugs and or Insulin therapy on diabetes induced RBC membrane lipid alteration is not established. Hence the present work was undertaken to study the influence of anti diabetic drugs and or Insulin on RBC membrane lipid composition in type 2 diabetic subjects. Blood samples from randomly selected type 2 diabetic subjects were collected after obtaining written consent. The plasma lipids as well as RBC membrane lipids were estimated. The study group include normal subjects (group-1), control diabetics diabetic subjects (group-2), diabetic subjects receiving oral drugs (group-3), diabetic subjects receiving insulin (group-4) and diabetic subjects receiving both oral drugs and insulin (group-5).

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Influence of Anti Diabetic Therapy on Plasma Lipid Profile and Its Relation to Erythrocyte Membrane Lipid Levels in Type 2 Diabetic Subjects. (2013). Global Journal of Medical Research, 12(11), 9-16. https://medicalresearchjournal.org/index.php/GJMR/article/view/340

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References

(2004) Dyslipidemia Management in Adults With Diabetes. 27(suppl_1), s68-s71.

P Agutter, J Cockrill, J Lavine, B Mc Caldin, R Sim (1979) Properties of mammalian nuclearenvelope nucleoside triphosphatase. 181, 647-658.

L Aiello, L Rand, J Sebastyen, J Weiss, M Bradbury, M Wafai, J Briones (1985) The Eye and Diabetes, in Joslin's Diabetes Mellitus. 12, 600-634.

Juhan Vague, J Dris, Roul Cedel (1984) Abnormalities of myth membrane lipids in insulin dependent diabetics are improved by shorter term control of diabetes. 4, 455-459.

Basavaraj Aski, G Rudrappa, R Kashinath (2010) Influence of Serum Lipid Levels on Erythrocyte Membrane Lipid Composition in Diabetes Mellitus. 2(1), 15-23.

Richard Henary, Etal (1974) Unknown Title. 25, 1285-1289.

K Choudhary (1989) Copyright page. iv.

J Richard, Henry (1974) Clinical chemistry principles and practice 2 nd edn. 28, 1438-1441.

K Herbert, Lipid Clinical chemistry: Theory, Analysis, correlation.

T Grove (1979) Effect of reagent pH on determination of high density lipoprotein cholesterolby precipitation with sodium phosphor tungstate magnesium. 25, 560-564.

R Nath (1990) Practical Biochemistry in clinical medicine.

R Nath (1990) Practical Biochemistry in clinical medicine 2 nd edn. 112-141.

Dang Aq, F Fass, Corter (1984) Unknown Title. 19, 738-748.

S Locke, D Tarsy (1985) The nervous system and diabetes in Joslin's diabetes mellitus. 12, 664-685.

Ukdds Group (1997) U.K. Prospective Diabetes Study 27: Plasma lipids and lipoproteins at diagnosis of NIDDM by age and sex. 20(11), 1683-1687.

(1985) Report of WHO study group. 727.

Christopher Stubbs, Anthony Smith (1984) The modification of mammalian membrane polyunsaturated fatty acid composition in relation to membrane fluidity and function. 779(1), 89-137.

R Abbott, P Wilson, W Kannel, W Castelli (1988) High density lipoprotein cholesterol, total cholesterol screening, and myocardial infarction. The Framingham Study.. 8(3), 207-211.

Abdul Hamid Zargar, Farooq Ahmad Wandroo, Mool Brahman Wadhwa, Bashir Ahmad (1995) Serum lipid profile in non insulin dependent diabetes mellitus dissociated with obesity. 15.

P Grant, T Coombs, B Frank (1972) Differences in the nature of the interaction of insulin and proinsulin with zinc. 126(2), 433-440.

Harper, ; Biochemistry, K Robert, Peter Murray, Daryl Mayes, Grannes Victor, W Rodwell (2000) Unknown Title.

K Robert, Murray (2000) Unknown Title. 25, 285-295.

David James, Robert Brown, Javier Navarro, Paul Pilch (1988) Insulin-regulatable tissues express a unique insulin-sensitive glucose transport protein. 333(6169), 183-185.

E Karnieli, M Zarnowski, P Hissin, I Simpson, L Salans, S Cushman (1981) Insulin-stimulated translocation of glucose transport systems in the isolated rat adipose cell. Time course, reversal, insulin concentration dependency, and relationship to glucose transport activity.. 256(10), 4772-4777.

D Calderhead, G Lienhard (1988) Labeling of glucose transporters at the cell surface in 3T3-L1 adipocytes. Evidence for both translocation and a second mechanism in the insulin stimulation of transport.. 263(25), 12171-12174.

P Nehal, Venugopal, Z Najma, Baquer (1990) Changes in lipid composition of red blood cells in hyperglycemic rats. 22(2), 43-248.

Domenico Prisco, Rita Paniccia, Mirella Coppo, Dino Vanni, Pier Rogasi, Manuela Tramontana, Rosanna Abbate, Gian Gensini (1989) Red blood cell lipid alterations in type II diabetes mellitus. 54(6), 751-758.

Michael Brown, Petri Kovanen, Joseph Goldstein (1981) Regulation of Plasma Cholesterol by Lipoprotein Receptors. 212(4495), 628-635.

H Varly (1980) Lipid and lipoproteins.

K Sushil, Jain (1985) In vivo externalization of phosphotidyl choline and phosphotidyl ethanolamine in membrane bilayer and hyperactive coagulability by lipid peroxidation of erythrocytes of rats. 76(1-3), 281-285.

M S Brown, P Kowanin, J Goldstein (1981) Unknown Title. 212, 628.

R O'brien, D Granner (1991) Regulation of gene expression by insulin. 278(3), 609-619.

A Tall, D Small (1978) New England. 299, 1232.

Walter Mcconathy, Petar Alaupovic (1976) Studies on the isolation and partial characterization of apolipoprotein D and lipoprotein D of human plasma. 15(3), 515-520.

George Steiner (1994) The dyslipoproteinemias of diabetes. 110, S27-S33.

H Varley, H Alan, Maurice (2007) Brittain, William James, (22 July 1905-12 July 1977), Chairman: Brittain Publishing Co. (London) Ltd; Brittain Publishing Co. (Canada) Ltd; London and Local Newspapers Ltd; Brittain Newspapers Ltd; Latin-American Trade Ltd; World Trade Publishing Co. Ltd; Indicator Newspapers Ltd; West London Chronicle Ltd; Practical Banking Ltd. 625-685.

Rfa Zwaal, P Comfurius, L Van Deenen (1977) Membrane asymmetry and blood coagulation. 268(5618), 358-360.