Effect of Oral Administration of Chloramphenicol on Hematological Profile of Male Charles Foster Rats
Keywords:
CAP, hematotoxicity, blood cells, CF rats
Abstract
For a given organism, relevant information about the internal environment can be easily accessed by its hematological profile. Chloramphenicol being a potent broad spectrum antibiotic is used readily in eyed drop formulations and is also in food industry. In the present study, varying doses (750, 1500 and 2250 mg/kg B.Wt) of Chloramphenicol (CAP) was administered orally as single daily dosage for 24 days to Male Charles Foster rats, to assess the hematological changes associated with oral exposure to the drug. The results showed a significant (p
Downloads
- Article PDF
- TEI XML Kaleidoscope (download in zip)* (Beta by AI)
- Lens* NISO JATS XML (Beta by AI)
- HTML Kaleidoscope* (Beta by AI)
- DBK XML Kaleidoscope (download in zip)* (Beta by AI)
- LaTeX pdf Kaleidoscope* (Beta by AI)
- EPUB Kaleidoscope* (Beta by AI)
- MD Kaleidoscope* (Beta by AI)
- FO Kaleidoscope* (Beta by AI)
- BIB Kaleidoscope* (Beta by AI)
- LaTeX Kaleidoscope* (Beta by AI)
How to Cite
References
A Kayode, O Kayode, O Aroyeun, M Stephen (2011) Haematologic and hepatic enzyme alterations associated with acute administration of Antiretroviral drugs. 6, 293-302.
A Turton, C Andrews, A Harvard, T Williams (2002) Studies on haematotoxicity of chloramphenicol succinate in Dunkin Hartley guinea pig. 5, 225-238.
A Yunis (1989) Chloramphenicol toxicity: 25 years of research. 3, 44N-48N.
Adel Yunis (1973) Reversible Bone Marrow Suppression From Chloramphenicol. 126(2), 272.
A Beamonte, F Goldfain-Blanc, N Casadevall, D Bazot, H Bertheux, N Claude (2005) A case of drug-induced hematotoxicity: from in vivo to in vitro assessment. 14(1), 61-65.
A Solanke, V Singh (2000) Haematological changes in rat, Rattus rattus after repeated exposure to thiodan 35. 18, 529-531.
Ashraf Emara, Mona Abo El-Noor, Neven Hassan, Ayman Wagih (2010) Immunotoxicity and hematotoxicity induced by tetrachloroethylene in egyptian dry cleaning workers. 22(2), 117-124.
A Attia, F Ibrahim, G Nabil, S Aziz (2013) Antioxidant effects of whole ginger (Zingiber officinale Roscoe) against lead acetateinduced hematotoxicity in rats. 7(17), 1108-1113.
A Ologundudu (2010) Prevention of 2, 4-dinitrophenylhydrazine-induced Tissue Damage in Rabbits by Orally Administered Decoction of Dried Flower of Hibiscus sabdariffa L.. 5(3), 208-211.
A Obianime, J Aprioku, C Esomonu (2011) The Effects of Aqueous Ocimum gratissimum Leaf Extract on Some Biochemical and Hematological Parameters in Male Mice. 4(1), 44-52.
Basanta Das, Subhas Mukherjee (2003) Toxicity of cypermethrin in Labeo rohita fingerlings: biochemical, enzymatic and haematological consequences. 134(1), 109-121.
C Jensen, D Jollow (1991) the role of Nhydroxyphenetidine in phenacetin-induced hemolytic anemia. 111(1), 1-12.
C Ambeker, B Cheung, J Lee, L Chan, R Liang, C Kumana (2000) Metabolism of chloramphenicol succinate in human bone marrow. 56, 405-409.
Ching-Hao Li, Yu-Wen Cheng, Po-Lin Liao, Ya-Ting Yang, Jaw-Jou Kang (2010) Chloramphenicol Causes Mitochondrial Stress, Decreases ATP Biosynthesis, Induces Matrix Metalloproteinase-13 Expression, and Solid-Tumor Cell Invasion. 116(1), 140-150.
C Kong, D Holt, S Ma, A Lie, L Chan (2000) Effects of antioxidants and a caspase inhibitor on chioramphenicol-induced toxicity of human bone marrow and HL-60 cells. 19(9), 503-510.
D Eppstein, C Kurahara, N Bruno, T Terrell (1989) Prevention of Doxorubicin-induced Hematotoxicity in Mice by Interleukin 1. 49, 3955-3960.
E Cundliffe, K Mcquillen (1967) Bacterial protein synthesis: the effects of antiobiotics. 30, 137-146.
E Edet, M Akpanabiat, F Uboh, T Edet, A Eno, E Itam, I Umoh (2011) Gongronema latifolium Crude Leaf Extract Reverses Alterations in Haematological Indices and Weight-loss in Diabetic Rats. 6(2), 174-181.
E Cronkite (1964) Enigmas underlying study of haemopoietic cell proliferation. 23, 649-661.
E Ikpeme, U Ekaluo, M (2011) Phytochemistry and haematological potential of ethanol seed, leaf and pulp extracts of Carica papaya (Linn.). 14, 408-411.
F Uboh, P Ebong, O Eka, E Eyong, M Akpanabiatu (2005) Effect Of Inhalation Exposure To Kerosene And Petrol-Fumes On Some Anaemia-Diagnostic Indices In Rats. 4(1), 59-63.
F Sanni, S Ibrahim, K Esievo, S Sanni (2005) Effect of oral administration of aqueous extract of Khaya senegalensis stem bark on phenylhydrazine-induced anaemia in rats. 8, 255-258.
G Agbor, J Oben, J Ngogang (2005) Haematinic activity of Hibiscus cannabinus. 4(8), 833-837.
G Carpenter (1975) Chloramphenicol eye drops and marrow aplasia [letter. 2, 326-327.
G Milhaud (1983) Milhaud, Darius, (4 Sept. 1892-22 June 1974), Grand Officier, Légion d'Honneur, 1965; composer; Hon. Professor of Composition, Conservatoire de Musique, Paris, 1947.
G Prasad, G Priyanka (2011) Effect of Fruit Rind Extract of Garcinia gummi-gutta on Haematology and Plasma Biochemistry of Catfish Pangasianodon hypophthalmus. 6(3), 240-251.
J Juaristi, M Aguirre, R Carmuega, M Romero-Benitez, M Alvarez, N Brandan (2001) Hematotoxicity induced by paclitaxel: in vitro and in vivo assays during normal murine hematopoietic recovery. 23(4), 161-167.
J Berger (2007) Phenylhydrazine Haematotoxicity. 5, 125-130.
Jung-Hoon Jee, Fatima Masroor, Ju-Chan Kang (2005) Responses of cypermethrin-induced stress in haematological parameters of Korean rockfish, Sebastes schlegeli (Hilgendorf). 36(9), 898-905.
N Kumar, Hanumanth Appa, Vishnu Priya (2006) A study on ocular manifestations of neurofibromatosis type-1 in rural population of Chittoor district, Andhra Pradesh. 13(2), 33-37.
M Rahman, M Siddiqui (2006) Hematological and clinical chemistry changes induced by subchronic dosing of a novel phosphorothion ate (RPR-V) in Wistar male and female rats. 29, 95-110.
M Irena, R Skolimowski, D Knight, Edwards (1983) Molecular basis of chloramphenicol and thiamphenicol toxicity to DNA in vitro. 12(6), 534-542.
M Paape, S Nickerson, G Ziv (1990) In vivo effects of chloramphenicol, tetracycline, and gentamicin on bovine neutrophil function and morphologic features. 51, 1055-1061.
Murray Rich, Robert Ritterhoff, Robert Hoffmann (1950) A FATAL CASE OF APLASTIC ANEMIA FOLLOWING CHLORAMPHENICOL (CHLOROMYCETIN) THERAPY. 33(6), 1459-1467.
N Choudhary, S Joshi (2002) Reproductive Toxicity of Endosulfan in Male Albino Rats. 70(2), 285-289.
P Akah, C Okolo, A Ezike (2009) the haematinic activity of the methanol leaf extract of Brillantasia nitens Lindau (Acanthaceae) in rats. 8(10), 2389-2393.
P Akah, C Okolo, T Okoye, N Offiah (2010) Aqueous extract and methanol fractions of the leaves of Brillantasia nitens Lindau. Reverses phenylhydrazine -induced anaemia in rats. 4(3), 271-277.
P Eyer, E Lierheimer, M Schneller (1984) Reactions of nitrosochloramphenicol in blood. 33(14), 2299-2308.
Richard Gleckman (1975) Warning-Chloramphenicol May Be Good for Your Health. 135(8), 1125.
R Holt (1967) THE BACTERIAL DEGRADATION OF CHLORAMPHENICOL. 289(7502), 1259-1260.
R Rosenthal, A Blackman (1965) Bone marrow hypoplasia following use of chloramphenicol eyedrops. 191, 136-173.
R Snyder, C Hedli (1996) An overview of benzene metabolism.. 104(suppl 6), 1165-1171.
S Kowalczyk -Bronisz, J Gieldanowaki, B Bubak (1990) Immunological profile of animals exposed to pesticide--deltamethrin. 38(3 -4), 229-238.
S Jain, D Subrahmanyam (1978) On the mechanism of phenylhydrazine-induced hemolytic anemia. 82(4), 1320-1324.
Steven Abrams, T Degnan, V Vinciguerra (1980) Marrow Aplasia Following Topical Application of Chloramphenicol Eye Ointment. 140(4), 576.
S Kolawole, O Kolawole, M Akanji (2011) Effects of Aqueous Extract of Khaya senegalensis Stem Bark on Biochemical and Hematological Parameters in Rats. 6(6), 602-607.
S Saha, M Mukhopadhyay, P Ghosh, D Nath (2012) Effect of Methanolic Leaf Extract of Ocimum basilicum L. on Benzene-Induced Hematotoxicity in Mice.
S Thakur, M Eswaran, S Rajalakshmi (2012) Amelioration of carbamazepine induced oxidative stress and hematotoxicity by vitamin C. 2(3), 173-180.
T Fujitani, Y Tada, A Noguchi, M Yoneyama (2001) Effects of chlorpropham (CIPC) on the hemopoietic system of rats. 39(3), 253-259.
V Hymavathi, L Rao (2000) Effect of sublethal concentrations of lead on the haematology and biochemical constituents of Channa punctatus. 19, 1-5.
Y Savithri, P Sekhar, P Doss (2010) Changes in hematological profiles of albino rats under chlorpyrifos toxicity. 1, 1-7.
Published
2013-07-10
Issue
Section
License
Copyright (c) 2013 Authors and Global Journals Private Limited
This work is licensed under a Creative Commons Attribution 4.0 International License.