Abstract

Backgrounds The objective of the present study was to compare the postoperative analgesic effects of pre-emptive intravenous IV paracetamol lornoxicam and placebo following third molar surgery Materials and Methods This was a prospective double-blind randomized placebo-controlled study where 50 patients had both of their identical impacted mandibular third molars impacted Before the removal of the impacted third molar tooth on one side either of the two drug regimens 1g paracetamol or 8 mg lornoxicam administered preemptively and 15 days later second surgical approach was performed but this time for comparison the other drug regimen which was not chosen initially was carried out as the preemptive agent and all of the operations were performed by the same surgeon Diclofenac sodium up to 75 mg daily was provided as rescue medication The postoperative rescue analgesic consumption was recorded and pain scores were evaluated with a Verbal Rating Scale VRS at 15 30 min and 1 2 4 6 12 24 h postoperatively Results There was a significant difference in mean second hour VRS scores between paracetamol and lornoxicam group in favor of the lornoxicam p 0 05 But conversely there was no statistically significant difference in the need of use and the consumption of rescue analgesic medication between two drug groups Conclusion Pre-emptive IV paracetamol and lornoxicam effectively decreased the pain scores as compared to placebo in third molar surgery