Abstract

Rheumatoid arthritis (RA) is a common inflammatory disease associated with many extra-articular features. The aim of the current study is to assess the influence of omega-3 fatty acids (EPA,DHA) on serum lipids in patients with active RA. Fifty patients with active RA using MTX were participated in this study. Patients were allocated to take either omega-3 (1000 mg) capsule three times daily or capsules prefilled with glucose as placebo and were evaluatedat zero time (baseline) and after 12 weeks for lipid profile parameters. The RA disease activity was measured using DAS28-ESR and CDAI. After 12 weeks of starting adjuvant treatment with either omega-3 or placebo, it's found that only TG decreased significantly by omega-3 (plt;0.01) while other parameters (TC, HDL-c, LDL-c) showed no significant difference between the effect of omega- 3 and placebo. In Conclusion, omega-3 significantly decreased TG levelin patient with active rheumatoid arthritis.