Effect of Omega-3 as Adjuvant Therapy to Methotrexate on Lipid Profile in Iraqi Patients with Active Rheumatoid Arthritis

Shaimaa Saleh Khider

Authors

Shaimaa Saleh Khider

Keywords:

rheumatoid arthritis, omega-3, lipid profile

Abstract

Rheumatoid arthritis (RA) is a common inflammatory disease associated with many extra-articular features. The aim of the current study is to assess the influence of omega-3 fatty acids (EPA,DHA) on serum lipids in patients with active RA. Fifty patients with active RA using MTX were participated in this study. Patients were allocated to take either omega-3 (1000 mg) capsule three times daily or capsules prefilled with glucose as placebo and were evaluatedat zero time (baseline) and after 12 weeks for lipid profile parameters. The RA disease activity was measured using DAS28-ESR and CDAI. After 12 weeks of starting adjuvant treatment with either omega-3 or placebo, it's found that only TG decreased significantly by omega-3 (p

Downloads

How to Cite

Effect of Omega-3 as Adjuvant Therapy to Methotrexate on Lipid Profile in Iraqi Patients with Active Rheumatoid Arthritis. (2013). Global Journal of Medical Research, 13(B5), 19-23. https://medicalresearchjournal.org/index.php/GJMR/article/view/384

Download Citation

References

V Kumar, A Abbas, N Fausto, R Mitchell (2007) Robbins Basic Pathology. 5, 145-147.

R James, Rheumatoid (2004) CECIL text book of medicine, 22thedn. 1644-1654.

R Walker, C Whittlesea (2007) Clinical pharmacy and therapeutics. 53, 759-775.

M Kaplan (2006) cardiovascular disease in rheumatoid arthritis. 18, 289-297.

M Nurmohamed (2007) Atherogenic lipid profiles and its management in patients with rheumatoid arthritis. 3, 845-852.

Paulo Nicola, Hilal Maradit‐kremers, Véronique Roger, Steven Jacobsen, Cynthia Crowson, Karla Ballman, Sherine Gabriel (2005) The risk of congestive heart failure in rheumatoid arthritis: A population‐based study over 46 years. 52(2), 412-420.

E Choy, N Sattar (2009) Interpreting lipid levels in the context of high-grade inflammatory states with a focus on rheumatoid arthritis: a challenge to conventional cardiovascular risk actions. 68, 460-469.

C Christina, M David, Y Yuen (2011) Oxidation products of arachidonic acid and linoleic acid are increased in high density lipoprotein and low density lipoprotein from patients with active rheumatoid arthritis. 63(10), 763.

Athanasios Georgiadis, Paraskevi Voulgari, Maria Argyropoulou, Yannis Alamanos, Moses Elisaf, Alexandros Tselepis, Alexandros Drosos (2008) Early Treatment Reduces the Cardiovascular Risk Factors in Newly Diagnosed Rheumatoid Arthritis Patients. 38(1), 13-19.

R Oh (2005) Practical Applications of Fish Oil ( -3 Fatty Acids) in Primary Care. 18(1), 28-36.

M Mckenney, D Sica (2007) Prescription omega-3 fatty acids for the treatment of hypertriglyceridemia. 64(6), 595-605.

Leslie Cleland, Michael James, Susanna Proudman (2003) The Role of Fish Oils in the Treatment of Rheumatoid Arthritis. 63(9), 845-853.

B Olendzki, K Leung, G Reed (2011) Treatment of rheumatoid arthritis with marine and botanical oils: influence on serum lipids.Evidence-based complementary and alternative medicine. 9.

F Arnett, S Edworthy, D Bloch (1988) The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. 31, 315-324.

M Prevoo, M Van't Hof (1995) Modified disease activity scores that include twenty-eightjoint counts.Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. 38, 44-48.

D Aletaha, J Smolen (2005) The simplified disease activity index(SDAI) and clinical disease activity index(CDAI):A review of their usefulness and validity in rheumatoid arthritis. 23(39), 100-S108.

William Friedewald, Robert Levy, Donald Fredrickson (1972) Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge. 18(6), 499-502.

A Georgiadis, E Papavasiliou, E Lourida (2006) Atherogenic lipid profile is a feature characteristic of patients with early rheumatoid arthritis: effect of early treatment -a prospective, controlled study. 8(3), 82.

Milenko Lazarevic, Jelena Vitic, Vlastimir Mladenovic, Barry Lee Myones, John Skosey, William Swedler (1992) Dyslipoproteinemia in the course of active rheumatoid arthritis. 22(3), 172-180.

J Willers, S Fasse, N Putschky (2011) Combined add-on supplementation of omega-3 fatty acids, vitamin E, vitamin A, copper, and selenium in rheumatoid arthritis. 2, 714-723.

W Harris (1997) n-3 fatty acids and serum lipoproteins: human studies. 65, 1645S-1654S.