Abstract

The present experiment was designed to develop colon specific drug delivery system of ketorolac tromethiamine KT for treatment of various colonic disorders Matrix tablets were prepared by direct compression technique utilizing combination of guar gum with various types of biodegradable pH dependent hydrophilic retarders Tablets evaluated for quality control tests and in-vitro liberation studies 24h In vivo roentogenographic studies and stability studies performed for optimized formulation KT containing combination of guar gum with HPMCP Hypromellose Phthalate 55S released negligible amount in 1 2 pH and 7 4 phosphate buffers and 70 released in 6 8 pH simulated colonic fluid whereas 95 of KT released in 6 8 pH buffer ratcaecal content In-vivo roentogenographic studies of optimized formulation F10 showed location of the tablet at 30 mins 3 h and 8 h was in stomach caecum and ascending colon respectively FT-IR DSC reveals that no interaction between drug and used excipients