Colourimetric Assay of Atomoxetine Hydrochloride by Simple Aurum Coupling Reaction in Bulk and Tablet  Dosage Form

B. Mohammed Ishaq

Authors

B. Mohammed Ishaq

Keywords:

atomoxetine hydrochloride, spectrophotometric, ringbom#x2019;s plot, pharmaceutical formulations

Abstract

Simple, rapid and sensitive spectrophotometric procedure was developed for the analysis of atomoxetine hydrochloride (ATH) in pure form as well as in pharmaceutical formulations. The method was based on the reaction of ATH with gold (III) chloride in the pH range 3.5-4.5 forming violet colored complex solution, showing absorption maxima at 550 nm. The linear plot indicates that Beer's law is obeyed in the range of 5 -80 μg/ml of atomoxetine hydrochloride. The molar absorptivity and Sandell's sensitivity are 3.77 x 103M and 0.0774 μg cm-2 respectively. The standard deviation of the method for ten determinations ATH is 9.9827 x 103. The correlation coefficient (r2) of the experimental data of the calibration plot is 0.9997. The effective range of concentration for accurate determination of ATH as ascertained from Ringbom's plot and it is 10 -80 μg/ml.

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How to Cite

Colourimetric Assay of Atomoxetine Hydrochloride by Simple Aurum Coupling Reaction in Bulk and Tablet Dosage Form. (2014). Global Journal of Medical Research, 13(B7), 71-74. https://medicalresearchjournal.org/index.php/GJMR/article/view/428

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References

S Faraone, J Sergeant, C Gillberg, J Biederman (2003) Unknown Title. 2, 104.

John Mullen, Richard Shugert, George Ponsler, Qimin Li, Bhaskar Sundaram, Heather Coales, Joseph Yakupkovic, Richard Lelacheur, William Wheeler, Frank Belas, John-Michael Sauer (2005) Simultaneous quantification of atomoxetine as well as its primary oxidative and O-glucuronide metabolites in human plasma and urine using liquid chromatography tandem mass spectrometry (LC/MS/MS). 38(4), 720-733.

Z Hao-Jie, W Jun-Sheng, J Donovan, C Devane, B Gibson, J Markowitz (2007) Unknown Title. 846(1-2), 351.

J Sauer, G Ponsler, E Mattiuz, A Long, J Witcher, H Thomasson (2003) Unknown Title. 31, 98.

Jennifer Witcher, Amanda Long, Brian Smith, John-Michael Sauer, John Heilgenstein, Timothy Wilens, Thomas Spencer, Joseph Biederman (2003) Atomoxetine Pharmacokinetics in Children and Adolescents with Attention Deficit Hyperactivity Disorder. 13(1), 53-63.

E Mattiuz, G Ponsler, R Barbuch, P Wood, J Mullen, R Shugert (2003) Unknown Title. 31, 88.

Jane Sellers, Bernard Olsen, Paul Owens, Peter Gavin (2006) Determination of the enantiomer and positional isomer impurities in atomoxetine hydrochloride with liquid chromatography using polysaccharide chiral stationary phases. 41(4), 1088-1094.

B Mohammed Ishaq, K Vanitha Prakash, G Krishna Mohan (2011) Analytical method development and validation of prasugrel in bulk and its pharmaceutical formulation using the RP-HPLC method. 2(3), 173-177.