The Effect of Oral Metronidazole in the Prevention of Preterm Labour among Pregnant Women with Bacterial Vaginosis
Keywords:
metronidazole, preterm labour, bacterial vaginosis
Abstract
Aim of the study: To evaluatethe effectiveness of oral metronidazole in prevention of preterm labouramong pregnant women with bacterial vaginosis. Settings and study design: An experimental (longitudinal-prospective) study done in Tikrit city between April 2011 and April 2012. Methods: A total number of 50 pregnant women in their midtrimester were included in the study, they received oral metronidazole 200 mg orally in two divided doses for 7 days,selection criteria include pregnant women with singleton viable pregnancy in midtrimester with intact membranes. Demographic profile and prolongation of pregnancy and neonatal outcome were recorded is special forms. Results: Oral metronidazole was not effective in prolongation of pregnancy despite its efficacy in eradicating bacterial vaginosis. Conclusion: Our findings suggest that second trimester screening and treatment of bacterial vaginosis during pregnancy with oral metronidazole is not effective regarding prolongation of pregnancy and preventing adverse neonatal outcome.
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References
M Klebanoff, Hauthj, R Heine (2004) Asymptomatic bacterial vaginosis in pregnancy with and without treatment. 190, 363-370.
Harald Leitich, Barbara Bodner-Adler, Mathias Brunbauer, Alexandra Kaider, Christian Egarter, Peter Husslein (2003) Bacterial vaginosis as a risk factor for preterm delivery: A meta-analysis. 189(1), 139-147.
D Paternoster, Ambrosinia Magginot (2004) Efficasy of an acidic vaginal gel on vaginal PH and interleukin-6 levels in low risk pregnant women. 15(3), 198-201.
Surasith Chaithongwongwatthana (2002) Single hydrogen peroxide vaginal douching versus single-dose oral metronidazole for the treatment of bacterial vaginosis. 187(6 Pt2), 228.
A Shennan, Crawshaws, Jonesg (2006) A randomized controlled trial of metronidazole for the prevention of preterm labour in women positive for cervicovaginal fetal fibronectin. 113(1), 65-74.
P Steyn, H Odendaal, J Schoeman, C Stander, N Fanie, D Grové (2003) A randomised, double-blind placebo-controlled trial of ascorbic acid supplementation for the prevention of preterm labour. 23(2), 150-155.
Mark Yudin, Daniel Landers, Leslie Meyn, Sharon Hillier (2003) Clinical and Cervical Cytokine Response to Treatment With Oral or Vaginal Metronidazole for Bacterial Vaginosis During Pregnancy. 102(3), 527-534.
Atef Darwish, Ehab Elnshar, Suha Hamadeh, Mohammad Makarem (2007) Treatment options for bacterial vaginosis in patients at high risk of preterm labor and premature rupture of membranes. 33(6), 781-787.
G Giuffrida, A Mangiacasale (2006) Bacterial vaginosis in pregnancy. 28(12), 539-543.
J Kurtzman, M Chandiramane, A Briley (2008) Quantitative fetal fibronectin screening at 24 weeks substantially discriminates the risk of recurrent preterm delivery in asymptomatic patients with prior preterm labour. 199(6 Suppl 1), 10.
P‐g Larsson, L Fåhraeus, B Carlsson, T Jakobsson, U Forsum (2006) Late miscarriage and preterm birth after treatment with clindamycin: a randomised consent design study according to Zelen. 113(6), 629-637.
R Amsel, P Totten, C Spiegel (1983) Non specificvaginitis. Diagnostic criteria and microbial and epidemiological associations. 74, 14-22.
R Nugent, M Krohn, S Hillier (1991) Reliability of diagnosing bacterial vaginosis is improved by a standardized method of gram stain interpretation. 29(2), 297-301.
H Rang, M Dale, J Ritter, R Flower (2007) Drugs used in the treatment of infections and cancer. 6, 647-660.
H Mcdonald, J O'loughlin, R Vigneswaran, P Jolley, J Harvey, A Bof, P Mcdonald (1996) Metronidazole treatment of bacterial vaginosis flora and its effect on preterm birth. 8(1_suppl), 37-38.
J Carey, Klebanoffm, Hauthj, R Heine (2004) Time course of the regression of asymptomatic bacterial vaginosis in pregnancy with and without treatment. 190, 363-370.
A Ugwumadu, F Reid, P Hay (2006) Oral metronidazole and histologic chorioamnionitis in women with abnormal vaginal flora. 107(4), 863-868.
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2014-02-22
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