Effect of Emblica Officinalis on Stress Induced Biochemical and Psychological Changes in Mice

D. Yashwanth Kumar

Authors

D. Yashwanth Kumar

Keywords:

stress, anxiety, emblica officinalis

Abstract

Emblica officinalis Gaertn. (Euphorbiaceae) [EO] fruit is traditionally used as a general health tonic in Ayurveda. In the present study the effect of alcoholic extract of EO fruits was evaluated on acute stress induced biochemical and psychological changes in mice. Acute stress was induced by restraint stress method and the effect of EO at the doses of 100, 250 and 500mg/kg was evaluated on levels of plasma glucose and corticosterone. The level of anxiety induced by acute stress was measured by subjecting the mice to elevated plus maze. The extract at the doses of 250mg/kg and 500mg/kg significantly countered the stress induced elevated plasma glucose and cortisol levels. Likewise, the extract at the doses of 250 and 500mg/kg increased the number of entries and time spent in the open arm in elevated plus maze. In conclusion the Emblica officinalis fruit extract significantly reduces the adverse effects of stress on physical and mental health.

Downloads

How to Cite

Effect of Emblica Officinalis on Stress Induced Biochemical and Psychological Changes in Mice. (2014). Global Journal of Medical Research, 13(G2), 25-28. https://medicalresearchjournal.org/index.php/GJMR/article/view/478

Download Citation

References

S Bhattacharya, A Muruganandam (2003) Adaptogenic activity of Withania somnifera: an experimental study using a rat model of chronic stress. 75(3), 547-555.

S Bhattacharya, A Bhattacharya, K Sairam, S Ghosal (2000) Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: an experimental study. 7, 463-469.

Gerard Dawson, Mark Tricklebank (1995) Use of the elevated plus maze in the search for novel anxiolytic agents. 16(2), 33-36.

Y Deole, S Chavan, B Ashok, B Ravishankar, A Thakar, H Chandola (2011) Evaluation of anti-depressant and anxiolytic activity of Rasayana Ghana Tablet (A compound Ayurvedic formulation) in albino mice. 32.

G Elliott, C Eisdorfer (1982) Stress and human health.

D Glick, D Recllich, L Seyniour (1964) Fluorometric determination of corticosterone and cortisol. 74, 653.

M Kalia (2005) Neurobiological basis of depression: an update. 54, 24-27.

K Khan (2009) Roles of Emblica officinalis in Medicine -A Review. 2(4), 218-228.

Anbrin Masood, Basudeb Banerjee, V Vijayan, Arunabha Ray (2003) Modulation of stress-induced neurobehavioral changes by nitric oxide in rats. 458(1-2), 135-139.

S Mora, R Millán, H Lungenstrass, G Díaz-Véliz, J Morán, M Herrera-Ruiz, J Tortoriello (2006) The hydroalcoholic extract of Salvia elegans induces anxiolytic- and antidepressant-like effects in rats. 106(1), 76-81.

D Philip, F Joan, R Peter (1994) Clinical Chemistry in Diagnosis and Treatment. 195.

Naila Rasheed, Ethika Tyagi, Ausaf Ahmad, Kiran Siripurapu, Shawon Lahiri, Rakesh Shukla, Gautam Palit (2008) Involvement of monoamines and proinflammatory cytokines in mediating the anti-stress effects of Panax quinquefolium. 117(2), 257-262.

P Riebling, G Walker (1975) Husa's Pharmaceutical Dispensing 6th ed. Edited by Eric W. Martin. Mack Publishing Co., Easton, Pa., 1966. vii+903pp. 18 × 26cm. Price $12.00. 55(10), 1158.

S Pemminati, H Gopalakrishna, A K Shenoy, S S Sahu, S Mishra, V Meti, N Vinod (2010) Antidepressant activity of aqueous extract of fruits of Emblica officinalis in mice. I.

A Trevor, W Way (2001) Sedative-hypnotic drugs. 364-381.

M Weiner, J Weiner (1994) Enhancement of Coherent Charge Oscillations in Coupled Quantum Wells by Femtosecond Pulse Shaping. WC.23.

(null) Figure 7: Effect of non-grazed and grazed on soil properties TN (g/kg), TP (g/kg), TK (g/kg), AN (mg/kg), AP (mg/kg) and AK (mg/kg) of alpine meadow between non-grazed and grazed treatment in 3 (0-10, 10-20 and 20-30 cm) soil depths..

(0.05) Figure 8. GDC-0810 antagonizes estrogen-independent ER.Y537S-expressing tumors in vivo.. 31.