Tranexamic Acid for Postpartum Haemorrhage: A Review

Suzanne Davis

Authors

Suzanne Davis

Keywords:

tranexamic acid, pregnancy, cesarean section, postpartum haemorrhage, bleeding, maternal mortality

Abstract

Post partum haemorrhage is the main cause of maternal mortality worldwide. Tranexamic acid is a cheap, easy to use and relatively safe medication that is gaining popularity as a management option for obstetric haemorrhage. It is already widely used to limit bleeding in trauma and many major surgeries. This review examines the evidence surrounding its use to control bleeding at the time of delivery.

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How to Cite

Tranexamic Acid for Postpartum Haemorrhage: A Review. (2014). Global Journal of Medical Research, 14(E1), 31-33. https://medicalresearchjournal.org/index.php/GJMR/article/view/550

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References

M Hogan, K Foreman, M Naghavi, S Ahn, M Wang, S Makela, A Lopez, R Lozano, C Murray (2010) Maternal mortality for 181 countries, 1980-2008: a systematic analysis of progress towards Millenium Development Goal 5. 375, 1609-1623.

(2007) Trends in Maternal Mortality: 1990 to 2015.

Natalia Novikova, G Hofmeyr (2011) Tranexamic acid for preventing postpartum haemorrhage. 7, 7872.

Christopher Dunn, Karen Goa (1999) Tranexamic Acid. 57(6), 1005-1032.

I Roberts, H Shakur, T Coats, B Hunt, E Balogun, L Barnetson (2013) The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients. 17(10).

K Wellington, A Wagstaff (2003) Tranexamic acid: a review of its use in the management of menorrhagia. 63(13), 1417-1433.

World Health Organization: WHO Guidelines for the Management of Postpartum Haemorrhage and Retained Placenta. 330.

H Abdel-Aleem, T Alhusaini, M Abdel-Aleem, M Menoufy, A Gülmezoglu (2013) Effectiveness of tranexamic acid on blood loss in patients undergoing elective cesarean section: randomized clinical trial. 26(17), 1705-1709.

Upasana Goswami, Sushmita Sarangi, Sunali Gupta, Savita Babbar (2013) Comparative evaluation of two doses of tranexamic acid used prophylactically in anemic parturients for lower segment cesarean section: A double-blind randomized case control prospective trial. 7(4), 427.

M Gohel, P Patel, G Ashoo, P Desai (2007) Efficacy of tranexamic acid in decreasing blood loss during and after cesarean section: a randomized case controlled prospective study. 57, 227-230.

M Gai, L Wu, Q Su, K Tatsumoto (2004) Clinical observation of blood loss reduced by tranexamic acid during and after caesarean section: a multicenter, randomized trial. 112, 154-157.

Kemal Gungorduk, Gokhan Yıldırım, Osman Asıcıoğlu, Ozgu Gungorduk, Sinem Sudolmus, Cemal Ark (2011) Efficacy of Intravenous Tranexamic Acid in Reducing Blood Loss after Elective Cesarean Section: A Prospective, Randomized, Double-Blind, Placebo-Controlled Study. 28(03), 233-240.

Ali Movafegh, Laleh Eslamian, Azita Dorabadi (2011) Effect of intravenous tranexamic acid administration on blood loss during and after cesarean delivery. 115(3), 224-226.

Jianjun Xu, Wei Gao, Yingnan Ju (2013) Tranexamic acid for the prevention of postpartum hemorrhage after cesarean section: a double-blind randomization trial. 287(3), 463-468.

Khing Rushulo (2013) Effect of Intravenous Administration of Tranexamic Acid in Reducing Blood Loss During and After Caesarean Section. 23(7), 459-462.

M Sentürk, Y Cakmak, G Yildiz, P Yildiz (2013) Tranexamic acid for cesarean section: a doubleblind, placebo-controlled, randomized clinical trial. 287(4), 641-645.

Ducloy-Bouthors (2011) High-dose tranexamic acid reduces blood loss in postpartum haemorrhage. 15, R117.

Ian Roberts, Haleema Shakur, Katharine Ker, Tim Coats (2012) Antifibrinolytic drugs for acute traumatic injury. 12, 4896.

Haleema Shakur, Diana Elbourne, Metin Gülmezoglu, Zarko Alfirevic, Carine Ronsmans, Elizabeth Allen, Ian Roberts (2010) The WOMAN Trial (World Maternal Antifibrinolytic Trial): tranexamic acid for the treatment of postpartum haemorrhage: an international randomised, double blind placebo controlled trial. 11(1), 40.