Low-Level Laser for Prevention of Chemotherapy-Induced Oral Mucositis in Pediatric Patients with Acute Leukemia, HC/UFMG 2012-2013

Natalice Sousa de Oliveira; Jos Carlos Serufo

Authors

Natalice Sousa de Oliveira
Jos Carlos Serufo

Keywords:

Abstract

Oral mucositis (OM) is the non-hematological toxicity with the highest prevalence and morbidity in anticancer treatment. This study evaluated the use of low-level laser for the prevention of chemotherapy-induced OM by comparing 101 cycles with prophylactic irradiation using a gallium aluminum arsenide (GaAlAs) laser diode (λ=660 nm; P=40 mW, dose of 4 J/cm²) and 121 cycles with no irradiation. The conditions associated with oral health, chemotherapy cycles, neutropenia patterns, infectious complications and nutritional status were evaluated. OM occurred in 41.9% of the cycles. The probability of developing OM in the final cycles (7 to 10) was 7.34 times higher than in the initial cycles (1 to 6); 4.19 times higher in febrile neutropenia than in physiological neutropenia; 2.08 times higher when a therapeutic antimicrobial drug was used; and 2.12 times higher when gingivitis was present.

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Low-Level Laser for Prevention of Chemotherapy-Induced Oral Mucositis in Pediatric Patients with Acute Leukemia, HC/UFMG 2012-2013. (2014). Global Journal of Medical Research, 14(J2), 7-10. https://medicalresearchjournal.org/index.php/GJMR/article/view/684

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