Abstract

The presence of a wide selection of angiotensin receptor blockers and the conflicting evidence regarding their cardioprotective effect led to the attempt to evaluate the impact of irbesartan and candesartan on cardiac hypertrophy and remodeling Female Albino rats were divided into 3 groups The first group served as the control group and was given 1 ml distilled water via oral gavage and 0 5 ml distilled water subcutaneously The second group was the isoproterenol ISO group and was given a daily S C injection of ISO at a dose of 5 mg kg The third group served as the treatment group and it was subdivided into 2 groups both received ISO as stated previously along with a treatment drug which was administered via oral gavage and they included ISO-Irb irbesartan 50 mg kg day and ISO-Cand candesartan 2 6 mg kg day All groups were treated for a period of 14 days The assayed parameters included mean serum Matrix metalloproteinase 9 MMP-9 Cardiac troponin I cTn-I and Heart weight to Body weight Hw Bw ratio Irbesartan coadministered with ISO significantly reduced mean serum MMP-9 concentration while candesartan significantly reduced MMP-9 and cTn-I concentrationscompared to the ISO group respectively The Hw Bw ratio was significantly reduced by both drugs In conclusion both treatment drugs possessed some degree of cardioprotection candesartan being the most beneficial in ameliorating isoproterenol induced cardiac injury