Abstract

Introduction: Tuberculosis continues to be one of the major public health problems in Ethiopia. In 2009 the country ranked 7th from the 22 TB high burden countries by estimated number of case. It is also showed that the country has lower treatment success rate sated by World Health Organization. Therefore, the aim of this study is to assess determinant factors of tuberculosis treatment failure among patients directly Observed therapy in Northern Ethiopia. Methods: Unmatched case-control study was conducted among randomly selected health facilities found in northern Ethiopia from February to October 2013. Samples were 77 cases and 153 controls recruited during the course of TB treatment. Cases were TB patients those declared as treatment failure and control were as cured after completion of the treatment (after 5 months of treatments). Both cases and controls were selected from TB clinics. Data were analyzed by SPSS version 16.0. Bivariate and multivariate logistic regression (Odds Ratio) with 95% CI was used to see the associations.