Assay for Quantitative Analysis of Losartan Potassium by using UV Spectroscopy

Zehra Ashraf; Nimra Waheed; Zehra Ashraf

Authors

Zehra Ashraf
Nimra Waheed
Zehra Ashraf

Keywords:

losartan potassium, anti-hypertensive, beta blockers

Abstract

Drug is a substance that brings about a change in the biological functions through its chemical actions. Drug losartan are the first marketed beta blockers of the angiotensin II-type (AT1) receptor. It is the prototypic ARB. Their pharmacologic effect are very similar to the ACE inhibitors, because they also produce the arteriolar and venous dilation and block aldosteron secretion, thus lowers the blood pressure, decreases the salt and water retention. Its chemical name is losartan potassium. It is indicated in mild to severe hypertension and contraindicated in pregnancy because it increases teratogenic risk and may leads to mal formation or death of fetus. It is light yellow solid and stable under recommended storage conditions, freely soluble in water and soluble in alcohol. Losartan inhibit the binding of angiotensin II to type 1 in tissue (kidney and adrenal gland) losartan and its active metabolite is more potent then losartan inhabitation causes vasodilation and decreases sodium and water retention. The aim of study is to determine the %age assay of losartan potassium of different brands.

Downloads

How to Cite

Assay for Quantitative Analysis of Losartan Potassium by using UV Spectroscopy. (2015). Global Journal of Medical Research, 15(B4), 35-37. https://medicalresearchjournal.org/index.php/GJMR/article/view/979

Download Citation

References

M Clark, R Finkel, J Rey, Whalen K (2012) antihypertensive", Lippincott's illustrated reviews pharmacology. 236.

Akriti Nepal, Chen Ding-Ding, Sufia Yasmeen, Nirmala Koju, Muhammad Abbas, Cao Teng-Li, Zhang Xiu Xiu (2012) A Review study on "The effect of Metoprolol and Losartan on Isoprenaline Induced Heart Failure Mice".. 4(12), 158-165.

Cornelis Boersma, Jarir Atthobari, Ron Gansevoort, Lolkje De Jong-Van Den Berg, Paul De Jong, Dick De Zeeuw, Lieven Annemans, Maarten Postma (2006) Pharmacoeconomics of Angiotensin II Antagonists in Type 2 Diabetic Patients with Nephropathy. 24(6), 523-535.

Julienne Kirk (1999) Pharm-d, wake forest university school of medicine. 59(II), 3140-3148.

Rafael Hernández-Hernández (2014) Angiotensin II receptor antagonists role in arterial hypertension.

Nafisur Rahman, Masoom Siddiqui, Syed Azmi (2006) Development and Validation of Kinetic Spectrophotometric Method for the Determination of Losartan Potassium in Pure and Commercial Tablets. 53(3), 735-743.

Karen Goa, Antona Wagstaff (1996) A Review of its Pharmacology, Clinical Efficacy and Tolerability in the Management of Hypertension. 51(5), 820-845.

S Shanmugam, Ramya Chakrahari, *, K Sundaramoorthy, T Ayyappan, T Vetrichelvan (2011) Formulation and Evaluation of Sustained Release Matrix Tablets of Losartan potassium. 3(1), 526-234.

M Barry, M Brenner, E Mark, M Cooper, D Ph, M Dick De Zeeuw, D Ph, F William, M Keane (2001) Effects of Losartan on Renal and Cardiovascular Outcomes in Patients with Type 2 Diabetes and Nephropathy. 345, 861-869.

George B Pylypchuk (1998) ACE Inhibitor-Versus Angiotensin II Blocker-Induced Cough and Angioedema. 32(10), 1060-1066.

S Alwan, *, J Polifka, J Friedman (2005) Angiotensin II receptor antagonist treatment during pregnancy. 73(2), 123-130.

K Yoshinaga (1999) Drug-interactions and adverse effects of losartan potassium, an angiotensin II receptor antagonist. 57(5), 1194-1197.

Domenic Sica (2005) Clinical Pharmacokinetics of Losartan. 44(8), 797-814.

Zehra Safila Naveed, Tasleem Ashraf, Mukhtar (2015) assay of different brands of cefadroxil by using spectrophotometric method. 12.

Zehra Safila Naveed, Tasleem Ashraf, Mukhtar (2015) Simultaneous Equation Method for the Estimation of Caffeine and Pioglitazone HCL by UV-Visible Spectrophotometry. 8(2), 24-029.

Safila Naveed (2015) Zehra ashraf and Muhammad tanweer alam, using UV spectrophotometric method to determine the linearity of vildagliptin brands.