Differences in Contrast-Enhanced CT Features Between Clear Cell Renal Carcinoma and Non- Clear Cell Renal Carcinoma

Abstract

Purpose Different RCC has different behavioral characteristics and their management protocol also different Our purpose was to differentiate clear cell renal carcinoma from Non clear cell renal carcinoma with the help of contrast enhanced CT imaging features which might help the clinician to make early decision about the management of renal cell carcinoma Materials and methods We retrospectively analyzed 64 patients 39 clear cell and 25 non clear cell of renal cell carcinoma RCC from February 2014 to February 2016 We excluded 2 cases of angiomyolipoma and one case of oncocytoma because of their benign characteristics So total number of non- clear cell renal carcinoma was 22 Two radiologists retrospectively reviewed CT studies in an independent and blinded fashion We compared Patient age and sex tumor size margin clear or ill defined location presence or absence of hemorrhage necrosis calcification degree of enhancement hypodense isodense or hyperdense pattern of enhancement homogenous or heterogeneous tumor spreading pattern including presence or absence of thrombus inferior vena cava and renal vein lymphadenopathy ascites We performed statistical analysis with the help of SPSS 17 1 Software Results In corticomedullary phase most of Clear cell RCC 21 of39 53 8 tended to show hyperdense enhancement whereas most of non- clear 21 of 22 95 showed hypodensity and only 1 of 22 5 showed isodensity When we compared homogeneity and heterogeneity in between two groups we found non- clear RCCs 86 were more heterogeneous than clear cell RCCS 53 P 0 05 ccRCC 15 of 39 38 5 usually located in middle pole whereas most of non- clear cell RCC 15 of 22 68 2 did not show any specific polarity predilection P 0 05 33 of 39 84 6 ccRCC involved medulla whereas 20 of 22 90 9 non clear cell RCC showed mixed involvement of cortex medulla and pelvis but no specific tendency to locate P 0 05 Calcification was more commo