Antivirt #xAE;{Al 4 (SiO 4 ) 3 + 3Mg 2 SiO 4 #x2192; 2Al 2 Mg 3 (SiO 4 ) 3 } Enhances Efficacy of Co-trimoxazole in Terminating Experimental Trypanosome Infections in Mice
Keywords:
cotrimoxazole; folic acid-inhibition; anti-trypanosomes efficacy; antivirt#xAE;; sleeping sickness, new medicine
Abstract
Both bacteria and protozoa require Folic acid for replication and Cotrimoxazole inhibits synthesis of the vitamin. For its mechanism of inhibiting Folic acid, the medicine has been in use as antibacterial drug for many decades but it is not being used to treat trypanosomosis (protozoan disease). To enhance anti-Folic acid activity of the medicine in order to improve its anti-trypanosome efficacy and make it function as new medicine for sleeping sickness (tropical disease of man and animals) it was stabilized with Antivirt#xAE; (Medicinal synthetic Aluminum-magnesium silicate). At 100 % of its antibacterial dose, Cotrimoxazole significantly reduced (P#x2264; 0.05) trypanosome parasitemia in mice, from 12.76#xB1;1.20 to 5 . 8 7#xB1; 0 .43. W hen i t w as s tabilized w ith t he A ntivirt#xAE;, 75 % of the antibacterial dose had slight reduction (P#x2265; 0.05) in the trypanosome parasitemia (11.30#xB1;1.01) while the 100 % -dose achieved zero (0.00#xB1;00) trypanosome parasitemia and improved total WBC counts (immunity) from 1.50#xB1;0.16 to 2.86#xB1;0.38.
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2020-05-15
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