Incidence of Carcinoma of the Prostate in Patients with Normal Prostatic Specific Antigen Following Prostatectomy

Abstract

Background Aims Prostate cancer is fourth most common male cancer recent data showed an increased incidence among Sudanese males and it is becoming a major medical problems and gained increased attention from Sudanese urologists Objective To detect patients with prostate cancer in prostatectomy specimens with normal preoperative PSA levels To try to suggest a base line level of PSA above which prostatectomy should not be performed unless having a histological tissue diagnosis Materials and methods This is descriptive prospective cross sectional hospital based study conducted at Soba University Hospital Omdurman Military Hospital IbnSina specialized Hospital in the period from September 2012 to August 2013All patients above 40 years of age undergoing prostectomy with normal PSA levels in the above mentioned hospitals were enrolled in this study their surgical specimens was sent for histology Results The PSA level was below 4ng ml in all cases with a mean of 1 85ng dl total and 0 36ng dl free PSA The histology of the prostatectomy specimens showed adenocarcinoma in 14 Pts 13 1 and BPH in 93 pts 86 7 Conclusion There was a detection rate of 13 1 among patients with PSA below ng ml with high grade Gleason scores Suspicious DRE in low PSA patients enhances the cancer detection rate