Genetic Epidemiological Studies of Hearing Loss in Faisalabad City, Pakistan

Fazeela Yaqoob; Sumaira Iqbal

Authors

Fazeela Yaqoob
Sumaira Iqbal

Keywords:

epidemiology, deafness, inheritance, pedigree

Abstract

Basic aim of the study was to investigate the incidence, prevalence, disease pattern and the etiology of the non-syndromic congenital deafness in a selected population from different areas and schools for special education of Faisalabad District, Pakistan. An epidemiological study was carried out through a questionnaire including different standard parameters like surname, parental marriage age, parental relationship of marriage, their family history including information about number of offspring, sex, birth order, number of normal and diseased individuals and age of onset. Information about economic status and educational qualification of parents, their locality, food habits and paternal smoking or non-smoking habits were also recorded. In a total of 436 deaf cases, 55.0% were males and 44.95% were females while 22 families were selected for pedigree analysis. Urban population (79.58%) was affected more than rural population (20.41%). Mean maternal and paternal marriage age was 20.63 ± 0.163 and 24.989 ± 0.217, respectively with smaller (0-4 years) marriage age difference.

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How to Cite

Genetic Epidemiological Studies of Hearing Loss in Faisalabad City, Pakistan. (2014). Global Journal of Medical Research, 14(F1), 1. https://medicalresearchjournal.org/index.php/GJMR/article/view/639

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References

L Aber, O Romano, G Halpern, I Livne, M Green, T Shohat (2005) Awareness about problems associated with consanguineous marriages: survey among Israeli Arab adolescents. 36, 530.

M Ansari, I Hirani, I Muhammad, S Zaidi, J Alam, F Naqvi (2004) Consanguinity, as a cause of deafness and hearing impairment in Karachi. 20(2), 22-26.

A Bafaqeeh, S Zakzouk, H Al-Muhammeid, R Essa (1994) Relevant demographic factors and hearing impairment in Saudi children: epidemiological study. 108, 294-298.

Abdulbari Bener, Rafat Hussain (2006) Consanguineous unions and child health in the State of Qatar. 20(5), 372-378.

A Bittles (2001) Consanguinity and its relevance to clinical genetics. 60(2), 89-98.

N Calapoglu, N Calapoglu, A Karaguzel (2005) Non syndromic recessive hearing loss linkaged TMPRSS3 gene in the Turkish population. 12(3), 31-35.

B Das (2006) The effect of Inbreeding on mortality and morbidity among Telugu-speaking populations of Kharagpur, west Bengal, India. 21(2), 151-163.

M Elahi, F Elahi, A Elahi, S Elahi (1998) Paediatric hearing loss in rural Pakistan. 27(6), 348-353.

Xavier Estivill, Paolo Fortina, Saul Surrey, Raquel Rabionet, Salvatore Melchionda, Leonardo D'agruma, Elaine Mansfield, Eric Rappaport, Nancy Govea, Montse Milà, Leopoldo Zelante, Paolo Gasparini (1998) Connexin-26 mutations in sporadic and inherited sensorineural deafness. 351(9100), 394-398.

Suneela Garg, Ritesh Singh, Shelly Chadha, Arunkumar Agarwal (2009) Cochlear implantation in India: A public health perspective. 65(3), 116.

R Hussain, A Bittles (1998) THE PREVALENCE AND DEMOGRAPHIC CHARACTERISTICS OF CONSANGUINEOUS MARRIAGES IN PAKISTAN. 30(2), 261-275.

A Kushki, B Zeyghami (2005) The effect of consanguineous marriages on congenital malformation. 10(5), 298-301.

X Liu, L Xu, S Zhang, Y Xu (1999) Epidemiological and genetic studies of congenital profound deafness in the general population of Sichuan, China. 36, 383-385.

S Longhitano, D Brunoni (2000) Genetic hearing loss: a study of 228 Brazilian. 15. patients. 23(1), 25-27.

Mary Marazita, Lynn Ploughman, Brenda Rawlings, Elizabeth Remington, Kathleen Arnos, Walter Nance (1993) Genetic epidemiological studies of early‐onset deafness in the U.S. school‐age population. 46(5), 486-491.

Albert Mehl, Vickie Thomson (2002) The Colorado Newborn Hearing Screening Project, 1992-1999: On the Threshold of Effective Population-Based Universal Newborn Hearing Screening. 109(1), e7-e7.

B Olusanya, D Swanepoel, M Chapchap, S Castillo, H Habib, S Mukari, N Martinez, H Lin, B Mcpherson (2007) Progress towards early detection services for infants with hearing loss in developing countries. 7, 14.

H Park, S Shaukat, X Liu, S Hahn, S Naz, M Ghosh, H Kim, S Moon, S Abe, K Tukamoto, S Riazuddin, M Kabra, R Erdenetungalag, J Radnaabazar, S Khan, A Pandya, S Usami, W Nance, E Wilcox, S Riazuddin, A Griffith (2003) Origins and frequencies of SLC26A4 (PDS) mutations in east and south Asians: global implications for the epidemiology of deafness. 40, 242-248.

M Reddy, L Bindu, P Reddy, P Rani (2006) Role of Consanguinity in Congenital Neurosensory Deafness. 6(4), 357-358.

P Reddy, Usha Rani, Mvv Reddy, Hema Bindu (2006) Role of intrauterine Rubella infection in the causation of congenital deafness. 12(3), 140.

R Santos, M Wajid, T Pham, J Hussan, G Ali, W Ahmad, S Leal (2005) Low prevalence of Connexin 26 (GJB2) variants in Pakistani families with autosomal recessive non-syndromic hearing impairment. 67, 61-68.

S Shami, L Schmitt, A Bittles (1990) Consanguinity, spousal age at marriage and fertility in seven Pakistani Punjab cities. 17, 97-105.

Patrick Willems (2000) Genetic Causes of Hearing Loss. 342(15), 1101-1109.

Sewall Wright (1992) Coefficients of Inbreeding and Relationship. 56(645), 330-338.

S Zakzauk (2002) Consanguinity and hearing impairment in developing countries: a custom to be discouraged. 116(10), 811-816.

Joel Zlotogora, Saleh Barges (2003) High Incidence of Profound Deafness in an Isolated Community. 7(2), 143-145.